Jon Krohn, Ph.D.

Here is the full list of references to my Oct. 10, 2014 LinkedIn post How To: Grow Your Own Brain Cells


1 Blakeslee, S. (2000, January 4) A decade of discovery yields a shock about the brain. New York Times

2 Altman, J. (1962) Are new neurons formed in the brains of adult mammals? Science 135, 1128-1129

3 Altman, J. (1963) Autoradiographic investigation of cell proliferation in the brains of rats and cats. The Anatomical Record 145, 573-591

4 Altman, J., and Das, G.D. (1965) Autoradiographic and histological evidence of postnatal neurogenesis in rats. Journal of Comparative Neurology 124, 319-335

5 Ramon y Cajal, S. (1928) Degeneration and regeneration of the nervous system. Oxford: Oxford University Press

6 Rakic, P. (1985) Limits of neurogenesis in primates. Science 227, 1054-1056

7 Cameron, H.A. et al. (1993) Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat. Neuroscience 56, 337-344

8 Kuhn, H.G. et al. (1996) Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. Journal of Neuroscience 16, 2027-2033

9 Reynolds, B.A. and Weiss, S. (1992) Generation of neurons and astrocytes from isolated cells of the adult nervous system. Science 255, 1707-1710

10 Kilpatrick, T.J. and Bartlett, P.F. (1993) Cloning and growth of multipotential neural precursors: requirements for proliferation and differentiation. Neuron 10, 255-265

11 Palmer T.D. et al. (1995) FGF-2-responsive neuronal progenitors reside in proliferative and quiescent regions of the adult rodent brain. Molecular and Cellular Neuroscience 6, 474-486

12 Eriksson, P.S. et al. (1998) Neurogenesis in the adult human hippocampus.Nature Medicine 4, 1313-1317

13 Altman, J. (1975) Postnatal development of the hippocampa dentate gyrus under normal and experimental conditions. In: The Hippocampus (Isaacson R.L and Pribram K.H., eds), pp 95-122. London: Plenum Press.

14 Kempermann, G. (2006) Adult Neurogenesis: Stem Cells and Neuronal Development in the Adult Brain. Oxford: Oxford University Press

15 Seri, B. et al. (2001) Astrocytes give rise to new neurons in the adult mammalian hippocampus. Journal of Neuroscience 21, 7153-7160

16 Filippov, V. et al. (2003) Subpopulation of nestin-expressing progenitor cells in the adult murine hippocampus shows electrophysiological and morphological characteristics of astrocytes. Molecular and Cellular Neuroscience 23, 373-382

17 Fukuda, S. et al. (2003) Two distinct subpopulations of nestin-positive cells in adult mouse dentate gyrus. Journal of Neuroscience 23, 9357-9366

18 Kempermann, G. et al. (2004) Milestones of neuronal development in the adult hippocampus. Trends in Neurosciences 27, 447-452

19 Brandt, M.D. et al. (2003) Transient calretinin-expression defines early postmitotic step of neuronal differentiation in adult hippocampal neurogenesis of mice. Molecular and Cellular Neuroscience 24, 603-613

20 Ambrogini, P. et al. (2004) Morpho-functional characterization of neuronal cells at different stages of maturation in granule cell layer of adult rat dentate gyrus. Brain Research 1017, 21-31

21 Rao, M.S. and Shetty, A.K. (2004) Efficacy of doublecortin as a marker to analyse the absolute number and dendritic growth of newly generated neurons in the adult dentate gyrus. European Journal of Neuroscience 19, 234-246

22 Carlen, M. et al. (2002) Functional integration of adult-born neurons. Current Biology 12, 606-608

23 Hastings, N.B. and Gould, E. (1999) Rapid extension of axons into the CA3 region by adult-generated granule cells. Journal of Comparative Neurology 413, 146-154

24 Markakis, E. and Gage, F.H. (1999) Adult-generated neurons in the dentate gyrus send axonal projections to the field CA3 and are surrounded by synaptic vesicles. Journal of Comparative Neurology 406, 449-460

25 Stanfield, B.B. and Trice, J.E. (1988) Evidence that granule cells genereated in the dentate gyrus of adult rats extend axonal projections. Experimental Brain Research 72, 399-406

26 Jessberger, S. and Kempermann, G. (2003) Adult-born hippocampal neurons mature into activity-dependent responsiveness. European Journal of Neuroscience18, 2707-2712

27 van Praag, H. et al. (2002) Functional neurogenesis in the adult hippocampus.Nature 415, 1030-1034

28 Cameron, H.A. and McKay, R.D. (1999) Restoring production of hippocampal neurons in old age. Nature Neuroscience 2, 894-897

29 Kempermann, G. et al. (1998) Experience-induced neurogenesis in the senescent dentate gyrus. Journal of Neuroscience 18, 3206-3212

30 Kempermann, G. et al. (1997) Genetic influence on neurogenesis in the dentate gyrus of adult mice. Proceedings of the National Academy of Sciences USA 94, 10409-10414

31 Bayer, S.A. et al. (1982) Neurons in the rat dentate gyrus granular layer substantially increase during juvenile and adult life. Science 216, 890-892

32 Peirce, J.L. et al. (2003) Genetic architecture of the mouse hippocampus: identification of gene loci with selective regional effects. Genes, Brain and Behavior2, 238-252

33 Crespo, D. et al. (1986) Evidence that late-generated granule cells do not simply replace earlier formed neurons in the rat dentate gyrus. Experimental Brain Research 62, 541-548

34 Seki, T. (2002) Expression patterns of immature neuronal markers PSA-NCAM, CRMP-4 and NeuroD in the hippocampus of young adult and aged rodents. Journal of Neuroscience Research 70, 327-334

35 Biebl, M. et al. (2000) Analysis of neurogenesis and programmed cell death reveals a self-renewing capacity in the adult brain. Neuroscience Letters 291, 17-20

36 Kempermann, G. and Gage, F.H. (2002) Genetic determinants of adult hippocampal neurogenesis correlate with acquisition, but not probe trial performance in the water maze task. European Journal of Neuroscience 16, 129-136

37 Kempermann, G. et al. (2003) Early determination and long-term persistence of adult-geerated new neurons in the hippocampus of mice. Development 130, 391-399

38 Leuner, B. et al. (2004) Learning enhances the survival of new neurons beyond the time when the hippocampus is required for memory. Journal of Neuroscience24, 7477-7481

39 Winner, B. et al. (2002) Long-term survival and cell death of newly generated neurons in the adult rat olfactory bulb. European Journal of Neuroscience 16, 1681-1689

40 Changeling Productions. Retrieved from on March 1, 2008

41 Freund, T.F. and Buzsaki, G. (1996) Interneurons of the hippocampus.Hippocampus 6, 347-470

42 Kolb, B. and Whishaw, I.Q. (2003) Fundamentals of Human Neuropsychology. New York: Worth Publishers

43 Eichenbaum, H. et al. (1999) The hippocampus, memory, and place cells: is it spatial memory or a memory space? Neuron 23, 209-226

44 Fortin, N.J. et al. (2002) Critical role of the hippocampus in memory for sequences of events. Nature Neuroscience 5, 458-462

45 Eichenbaum, H. (2003) How does the hippocampus contribute to memory?Trends in Cognitive Science 7, 427-429

46 Wirth, S. et al. (2003) Single neurons in the monkey hippocampus and learning of new associations. Science 300, 1578-1581

47 Nakazawa, K. et al. (2003) Hippocampal CA3 NMDA receptors are crucial for memory acquisition of one-time experience. Neuron 38, 305-315

48 Day, M. et al. (2003) Glutamate-receptor-mediated encoding and retrieval of paired-associate learning. Nature 424, 205-209

49 Morris, R.G. et al. (1982) Place navigation impaired in rats with hippocampal lesions. Nature 297, 681-683

50 van Praag, H. et al. (1999a) Running enhances neurogenesis, learning and long-term potentiation in mice. Proceedings of the National Academy of Science USA 96, 13427-13431

51 Kempermann, G. (2002) Why new neurons? Possible functions for adult hippocampal neurogenesis. Journal of Neuroscience 22, 635-638

52 Becker, S. (2005) A computational principle for hippocampal learning and neurogenesis. Hippocampus 15, 722-738

53 Wickott, L. et al. (2006) A functional hypothesis for adult hippocampal neurogenesis: avoidance of catastrophic interference in the dentate gyrus.Hippocampus 16, 329-343

54 Aimone, J.B. et al. (2006) Potential role for adult neurogenesis in the encoding of time in new memories. Nature Neuroscience 9, 723-727

55 Lee, J. et al. (2002) Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. Journal of Neurochemistry 82, 1367-1375

56 Kowalczyk, A. et al. (2004) The critical role of cyclin D2 in adult neurogenesis.Journal of Cell Biology 167, 209-213

57 Perfilieva, E. et al. (2001) Gender and strain influence on neurogenesis in dentate gyrus of young rats. Journal of Cerebral Blood Flow & Metabolism 21, 211-217

58 Kempermann, G. et al. (1997a) More hippocampal neurons in adult mice living in an enriched environment. Nature 386, 493-495

59 Amrein, I. et al. (2004) Marked species and age-dependent differences in cell proliferation and neurogenesis in the hippocampus of wild-living rodents.Hippocampus 14, 1000-1010

60 Gould, E. et al. (1999) Learning enhances adult neurogenesis in the hippocampal formation. Nature Neuroscience 2, 260-265

61 Kempermann, G. et al. (1998a) Environmental stimulation of 129/SvJ mice results in increased cell proliferation and neurogenesis in the adult dentate gyrus.Current Biology 8, 939-942

62 Kronenberg, G. et al. (2003) Subpopulations of proliferating cells of the adult hippocampus respond differently to physiologic neurogenic stimuli. Journal of Comparative Neurology 467, 455-463

63 Kempermann, G. et al. (2002) Neuroplasticity in old age: sustained five-fold induction of hippocampal neurogenesis by long-term environmental enrichment.Annals of Neurology 52, 135-143

64 van Praag, H. et al. (1999b) Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nature Neuroscience 2, 266-270

65 Kronenberg et al. (2006) Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus. Neurobiology of Aging 27, 1505-1513

66 Trejo, J.L. et al. (2001) Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus. Journal of Neuroscience 21, 1628-1634

67 Fabel, K. et al. (2003) VEGF is necessary for exercise-induced adult hippocampal neurogenesis. European Journal of Neuroscience 18, 2803-2812

68 Mirescu, C. et al. (2006) Sleep deprivation inhibits adult neurogenesis in the hippocampus by elevating glucocorticoids. Proceedings of the National Academy of Sciences USA 103, 19170-19175

69 Sohal, R.S. and Weindruch, R. (1996) Oxidative stress, caloric restriction, and aging. Science 273, 1346-1351

70 Lee, J. et al. (2000) Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats. Journal of Molecular Neuroscience 15, 99-108

71 Malberg, J.E., et al. (2000) Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. Journal of Neuroscience 20, 9104-9110

72 Santarelli, L. et al. (2003) Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301, 805-809

73 Castren, E. (2005) Is mood chemistry? Nature Reviews Neuroscience 6, 241-246

74 Comer, R.J. (2002) Fundamentals of Abnormal Psychology. New York: Worth Publishers

75 Nixon, K. and Crews, F.T. (2002) Binge ethanol exposure decreases neurogenesis in adult rat hippocampus. Journal of Neurochemistry 83, 1087-1093

76 Herrera, D.G. et al. (2003) Selective impairment of hippocampal neurogenesis by chronic alcoholism: protective effects of an antioxidant. Proceedings of the National Academy of Sciences USA 100, 7919-7924

77 Crews, F.T. et al. (2004) Exercise reverses ethanol inhibition of neural stem cell proliferation. Alcohol 33, 63-71

78 Abrous, D.N. et al. (2002) Nicotine self-administration impairs hippocampal plasticity. Journal of Neuroscience 22, 3656-3662

79 Lu, L. et al. (2003) Modification of hippocampal neurogenesis and neuroplasticity by social environments. Experimental Neurology 183, 600-609

80 Pham, K. et al. (2003) Repeated restraint stress suppresses neurogenesis and induces biphasic PSA-NCAM expression in the adult rat. European Journal of Neuroscience 17, 879-886

81 Malberg, J.E. and Duman, R.S. (2003) Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment.Neuropsychopharmacology 28, 1562-1571

82 Tanapat, P. et al. (2001) Exposure to fox odor inhibits cell proliferation in the hippocampus of adult rats via an adrenal hormone-dependent mechanism. Journal of Comparative Neurology 437, 496-504

83 Cameron, H.A. and Gould, E. (1994) Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus. Neuroscience 61, 203-209